1. Patients with viral cirrhosis who have not received antiviral therapy, liver cirrhosis of degree C in the stage of decompensation with acute hepatocellular insufficiency and with severe dysfunction of other organs and systems;
2. Patients with severe concomitant pathology,
3. Patients in acute conditions
4. Persistent cognitive impairment due to cerebrovascular and/or organic disease
5. Patients who consume alcohol and drugs
6. Pregnancy and lactation, cancer, age less than 18 years